Anatomic characteristics, identification, and protection of the nonrecurrent laryngeal nerve during thyroidectomy. 2011 Jan;121(1):164-6. doi: 10.1002/lary.21183. Spicy Food. For suspected liver injury, promptly discontinue PTU therapy and evaluate for evidence of liver injury and provide supportive care. Other proposed theories include alterations in tissue tolerance to THs, the presence of a unique catecholaminelike substance in thyrotoxicosis, and a direct sympathomimetic effect of TH as a result of its structural similarity to catecholamines. Your incision may appear red and hard at first,and you may notice some slight swelling and bruising around the scar. When injured, a person may have difficulty making high-pitched noises or yelling, though their routine speaking voice may be unchanged. Endocr J. See the image below. Thyroid storm is a clinical manifestation of an extreme hyperthyroid state that results in significant morbidity or disability or even death. Using pain medication after surgery may reduce discomfort, making it easier for you to keep moving your neck so that you have less stiffness later on. This theory also explains normal or low plasma levels and urinary excretion rates of catecholamines; however, it does not explain why beta-blockers fail to decrease TH levels in thyrotoxicosis. Since it's common for the parathyroid glands to function poorly after a thyroidectomy, you may be sent home with calcium and vitamin D supplements. Disclaimer. If you are not given calcium, it's important to be aware of the symptoms of hypocalcemia. Division of Endocrinology, The University of Texas Health Science Center at Houston, USA, Correspondence: Mohammed Hamdi, Division of Endocrinology, The University of Texas Health Science Center at Houston, USA, Received: September 03, 2021 | Published: September 20, 2021, Citation: Hamdi M, Chaudhri A, Shah N, et al. Patients with a BurchWartofsky Point Scale (BWPS) of 45 or Japanese Thyroid Association (JTA) categories of thyroid storm 1 (TS1) or thyroid storm 2 (TS2) with evidence of systemic decompensation require aggressive therapy. Mary Shomon is a writer and hormonal health and thyroid advocate. Regular thyroid function tests may need to be done, especially if you start to get symptoms of hypothyroidism. Phone: +36 180 38 002, Email: support@medcrave.com More Locations Although the exact pathogenesis of thyroid storm is not fully understood, the following theories have been proposed: Patients with thyroid storm reportedly have relatively higher levels of free THs than patients with uncomplicated thyrotoxicosis, although total TH levels may not be increased. Br J Anaesth. Some surgeons may reintroduce iodine for 10 days prior to surgery if subtotal thyroidectomy is planned. [Thyroid storm associated with multiorganic dysfunction]. Dare to Compare: Do You Know the Latest on Immuno-Oncology in Advanced Non-Small Cell Lung Cancer? Having a rapid heart rate (tachycardia) that can exceed 140 beats per minute. At your follow-up appointment, your surgeon will determine if you need to remain on calcium and vitamin D. If you were started on hormone replacement therapy, a thyroid-stimulating hormone test (TSH) should be checked about six weeks after surgery. When you visit the site, Dotdash Meredith and its partners may store or retrieve information on your browser, mostly in the form of cookies. Nausea and vomiting after thyroidectomy was the norm at one time, and people may be concerned if they talk with others who had this procedure in the past. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. It could take up to a week to treat what caused your thyroid storm. Roughly 5% of people may have temporary symptoms of a low calcium level, known as hypocalcemia, for at least a few weeks after thyroid surgery. encoded search term (Thyrotoxic Storm Following Thyroidectomy) and Thyrotoxic Storm Following Thyroidectomy, Hyperthyroidism, Thyroid Storm, and Graves Disease. Mimi S Kokoska, MD is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Association for Physician Leadership, American College of Surgeons, American Head and Neck SocietyDisclosure: Nothing to disclose. 22(2):263-77. Factors associated with mortality of thyroid storm: analysis using a national inpatient database in Japan. 43(4):1022-8. 2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition). TRAB was >40 IU/mL (normal <0.7 IU/mL). [Full Text]. If hypocalcemia is severe, the condition can progress to symptoms of abnormal heart rhythms (arrhythmias), difficulty breathing (due to muscle spasms in the voice box), kidney stones, heart failure, and/or seizures. If you are having thyroid surgery, known as a thyroidectomy, to remove all or part of your thyroid glanda butterfly shaped organ at the base of your neckit's important to know what to expect as you recover. Hamdi M, Chaudhri A, Shah N, et al. Lugol solution or saturated solution of potassium iodide can be used. . Symptoms and Signs of Thyroid Storm When Compared with Uncomplicated Thyrotoxicosis. Thyroidectomy then and now: a 50-year Australian perspective. Peter F Czako, MD, FACS is a member of the following medical societies: American College of Surgeons, American Medical Association, Michigan State Medical Society, American Association of Endocrine Surgeons, Detroit Surgical SocietyDisclosure: Nothing to disclose. Dysphagia, or swallowing problems, are common after thyroid surgery, though they usually don't last long, often resolving within two weeks. Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys. Patient was treated for thyroid storm with propylthiouracil, hydrocortisone, potassium iodide and propranolol. Thyroid Hormone Reference Range May Not Apply for Cancer Patients, FDA OKs Pembrolizumab for Adjuvant Treatment of NSCLC, Recognizing the Signs: Heart Failure and Type 2 Diabetes, Myopathies: Muscling Your Way to the Diagnosis. Gunateet Goswami, MD Consulting Staff, Internal Medicine Associates, Mount Clemens, Michigan; Consulting Staff, Department of Cardiology, Henry Ford Hospital Symptoms may include an area of firmness and swelling on the front or side of the neck (usually beneath the incision), neck pain, and symptoms of airway obstruction such as shortness of breath, lightheadedness, or stridor (a high-pitched wheezing sound that's usually most noticeable with inspiration than exhalation). If you have hyperthyroidism and are having thyroid surgery (thyroidectomy), your provider will most likely give you certain medication before the surgery to try to prevent thyroid storm. Outpatient versus inpatient thyroidectomy: A systematic review and meta-analysis. [QxMD MEDLINE Link]. Thyroid storm after thyroidectomy? In one study, the majority of patients with thyrotoxicosis were middle aged and white, and about 76% were female. Possible recommendations for . Thyroid storms are rare. PTU and MMI block the incorporation of iodine into thyroglobulin within 1 hour of ingestion. This can lead to a sore throat and the sensation of a lumplike something is stuck in your throatwith swallowing. Post operative expectations. Cardiac decompensation, although seen more frequently in elderly patients, may appear in younger patients and in patients without underlying cardiac disease. The decision was made to proceed with thyroidectomy. [Guideline] Satoh T, Isozaki O, Suzuki A, et al. official website and that any information you provide is encrypted Thyroid storm is a rare and life-threatening condition that can affect people with hyperthyroidism. Pokhrel B, Aiman W, Bhusal K. Thyroid Storm. You should also avoid any heavy lifting or strenuous activities, such as many sports, for a few weeks. 2017;157(2):210-216. doi:10.1177/0194599817700583, Myssiorek D, Ahmed Y, Parsikia A, Castaldi M, Mcnelis J. If youre experiencing symptoms of thyroid storm, such as a high fever and a fast heart rate, get to the nearest hospital immediately. [Full Text]. A 2018 study found that when a solution of potassium iodide was given prior to thyroid surgery for those with Grave's diseasea condition that can lead to an overactive thyroidit was associated with less temporary hypoparathyroidism and hoarseness. Generally speaking, you will usually need to return to the surgeon for a follow-up visit around one to two weeks after surgery. Peter F Czako, MD, FACS Chief, Division of Endocrine Surgery, Medical Director, North Tower Operating Rooms, Surgical Administration, William Beaumont Hospital; Associate Professor, Department of Surgery, Oakland University William Beaumont School of Medicine; Royal Oak Surgical Associates, PC In general, thyroid surgery is well tolerated and the vast majority of patients will have a smooth recovery. A drop in binding protein levels, which may occur postoperatively, might cause a sudden rise in free hormone levels. Br J Anaesth. Martin D. Disseminated intravascular . excessive release of thyroid hormones (THs), American Association of Endocrine Surgeons, American Association for the Advancement of Science, American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Association for Physician Leadership. PTU is considered as a second-line drug therapy, except in patients who are allergic or intolerant to methimazole, or for women who are in the first trimester of pregnancy. 2012 Sep. 109(3):466-7. [Guideline] Satoh T, Isozaki O, Suzuki A, et al. Mohananey D, Smilowitz N, Villablanca PA, et al. One week after thyroidectomy the patient was admitted with severe hyperthyroidism. Based on a work at https://medcraveonline.com Contact Us, 2014-2023 MedCrave Group. Endocr Pract. Bethesda, MD 20894, Web Policies The clinical picture relates to severely exaggerated effects of thyroid hormones (THs) due to increased release (with or without increased synthesis) or, rarely, increased intake of TH. Complications are much less common and can include neck bleeding, permanent hypoparathyroidism that requires ongoing calcium replacement, and damage to nerves that can lead to long-term hoarseness and vocal changes. Unauthorized use of these marks is strictly prohibited. Factors predictive of the development of surgical site infection in thyroidectomy - An analysis of NSQIP database. As far as safety, a 2018 study suggests that outpatient surgery may be safe, but the researchers admitted that the study may be biased (people who were are at greater risk are more likely to be hospitalized, whereas those at lower risk were more likely to be offered the procedure on an outpatient basis). This is because you'll no longer have a gland to make thyroid hormone and will experience symptoms of hypothyroidism, or an underactive thyroid, without replacement therapy. Multivitamins, especially vitamin B-1, are added to prevent Wernicke encephalopathy. Subsequent thyroid function tests showed TSH < 0.01 U/ml, FT3 25.0 pg/ml and FT4 8.0 ng/dl. Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, Tanaka Y. Thyroid. Propranolol blocks beta-adrenergic receptors and prevents conversion of T4 to T3. Venkata Subramanian Kanthimathinathan, MD Fellow in Bariatric/Advanced Laparoscopic Surgery, University of Missouri HealthcareDisclosure: Nothing to disclose. Adequate therapy should resolve the crisis within a week. Arlen D Meyers, MD, MBA Professor of Otolaryngology, Dentistry, and Engineering, University of Colorado School of Medicine Right femur biopsy was pursued, and it was consistent with metastatic carcinoma with primary thyroid features. Due to the rarity of this condition and its multitude of diverse presentations, diagnosis can be extremely challenging. We herein describe the case of a 37-year-old patient with a history of Graves' disease who was transferred to Tottori University Hospital with thyroid storm. National trends in incidence, mortality, and clinical outcomes of patients hospitalized for thyrotoxicosis with and without thyroid storm in the United States, 2004-2013. Glucocorticoids reduce iodine uptake and antibody titers of thyroid-stimulating antibodies with stabilization of the vascular bed. 2524 N. Broadway Edmond Oklahoma 73034. Arlen D Meyers, MD, MBA is a member of the following medical societies: American Academy of Facial Plastic and Reconstructive Surgery, American Academy of Otolaryngology-Head and Neck Surgery, American Head and Neck SocietyDisclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Cerescan; Ryte; Neosoma; MI10
Received income in an amount equal to or greater than $250 from: Neosoma; Cyberionix (CYBX)
Received ownership interest from Cerescan for consulting for: Neosoma, MI10. 2019 Jan. 29(1):36-43. [Full Text]. 2012 Jul. Head & Neck. Thyroid storm is the most severe form of hyperthyroidism, wherein organ failure begins to occur. For more information, see the FDA Safety Alert. Like your heart is going to beat out of your chest. Plasmapheresis, plasma exchange, peritoneal dialysis exchange transfusion, and charcoal plasma perfusion are other techniques used to remove excess circulating hormone. It is uncommon, but when it occurs after thyroidectomy, it is usually associated with Grave's disease. [2] Today, thyroid storm occurs more commonly as a medical crisis rather than a surgical crisis. [QxMD MEDLINE Link]. Symptoms of thyroid storm (severe thyrotoxicosis) include: Having a very rapid heartbeat. A seroma is a collection of fluid that can occur after many types of surgery. Br J Anaesth. Background Thyroid storm, also referred to as thyrotoxic crisis, is an acute, life-threatening, hypermetabolic state induced by excessive release of thyroid hormones (THs) in individuals with. If your healthcare provider prescribes thyroid replacement therapy, be sure to have a conversation with them before leaving the hospital about when to start the medication, which medication you need, and at what dosage. Management of thyroid storm is a multistep process. [QxMD MEDLINE Link]. Isabel Casimiro, MD, is board-certified in internal medicine and works as an endocrinologist at the University of Chicago. These hormones are vital to your body's proper function as they affect nearly every cell in your body. Fast Five Quiz: How Much Do You Know About Hyperthyroidism? encoded search term (Thyrotoxic Storm Following Thyroidectomy) and Thyrotoxic Storm Following Thyroidectomy, Hyperthyroidism, Thyroid Storm, and Graves Disease. Thyroidectomy is surgical removal of all or part of the thyroid gland, which is located in the front of the neck. The average age of a person who gets thyroid storm is 42 to 43 years. Thyroid storm is a medical emergency that is fatal if its not treated. Though thyroid surgery is considered a relatively safe procedure, complications may sometimes occur. 43(4):1022-8. Among 121,384 hospital discharges with thyrotoxicosis identified between 2004 and 2013, 19,723 (16.2%) were diagnosed with thyroid storm. Thyroid storm, also called thyrotoxic crisis, is a life-threatening medical emergency caused by very high levels of circulating thyroid hormone. If you are wondering what your scar may look like, the University of California Los Angeles has a scar gallery with photos of people who have had thyroid surgery at various points in the healing process. This excessive hypermetabolic state, with increased intestinal transit and tachypnea, leads to immense fluid loss. Cardiac findings of mild-to-moderate sinus tachycardia in thyrotoxicosis intensify to accelerated tachycardia, hypertension, high-output cardiac failure, and a propensity to develop cardiac arrhythmias. Healthcare providers may also rely on a physical examination to check for physical signs of thyroid storm, including: Since thyroid storm is a medical emergency, youll need to be treated for it in a hospital. Last reviewed by a Cleveland Clinic medical professional on 06/08/2022. Dare to Compare: Do You Know the Latest on Immuno-Oncology in Advanced Non-Small Cell Lung Cancer? The head of your bed will be raised to reduce swelling, and you will be allowed to eat a regular diet. Confusion, agitation, delirium, frank psychosis, seizures, stupor, or coma. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. If yours does not, talk to your surgeon about seeing a specialist in physical medicine and rehabilitation (a physiatrist) or a physical therapist who can work with you to improve the flexibility of your neck and design an exercise program to restore your neck mobility. These symptoms typically last for only a short time. In review of 41,835 patients with thyroid storm between 2003-2011, there was an increase in incidence of CS from 0.5% in 2003 to 3% in 2011 but a decrease in mortality from 60.5% in 2003 to 20.9% in 2011. Occurring in roughly one in 300 procedures, most hematomas occur within 24 hours of surgery, though research indicates they may occur later in 10% to 28% of cases. Thyroid surgery is often done under general anesthesia with a breathing tube placed in the windpipe, or trachea, to breathe for you. 2009 Feb. 102(2):193-5. Endoscopic thyroidectomy using the EZ-VANS method. Nagata T, Shimada Y, Miwa T, Hashimoto I, Kojima H, Okumura T, Tsukada K. Surg Today. Muller C, Perrin P, Faller B, Richter S, Chantrel F. Role of plasma exchange in the thyroid storm. Policy. If you experience itching, applying scar gel or aloe may provide relief, but talk to your surgeon before doing so. [1]. Feeling cold, especially in the extremities, Increased menstrual flow and more frequent periods, The presence of other medical conditions, such as congestive heart failure or a bleeding disorder, Thyroid cancer, especially when a central neck dissection is done to remove lymph nodes. Possible complications of general anesthesia may also occur since most thyroidectomies require it. Having regular thyroid testing done is also important, as hypothyroidism may not occur right away, or even for months or years. [QxMD MEDLINE Link]. Pathophysiologic mechanisms of Graves disease relating thyroid-stimulating immunoglobulins to hyperthyroidism and ophthalmopathy. Epub 2015 Feb 12. Thyroid storm is a medical emergency and needs to be treated in a hospital. Hyperpyrexia, temperature in excess of 38C, dehydration, 2. The four parathyroid glands lie on the back of the thyroid gland and are sometimes injured or removed during surgery. [9] : Central nervous system (CNS) dysfunction at admission, Lack of antithyroid drug and beta-blockade use, Need for mechanical ventilation and plasma exchange along with hemodialysis, In addition, CNS dysfunction of greater than mild severity appears to be a risk factor for mortality. National trends in incidence, mortality, and clinical outcomes of patients hospitalized for thyrotoxicosis with and without thyroid storm in the United States, 2004-2013. Hypothyroidism American Thyroid Association statement on outpatient thyroidectomy. The majority of patients with PDTC die of metastatic disease. Confusion, agitation, delirium, frank psychosis, seizures, stupor, or coma. . In turn, increased THs increase the density of beta-adrenergic receptors, thereby enhancing the effect of catecholamines. Lancet. MOJ Clin Med Case Rep. 2021;11(5):136. Terris DJ, Snyder S, Carneiro-pla D, et al. Of the adults, 12 deaths and 5 liver transplants occurred, and among the pediatric patients, 1 death and 6 liver transplants occurred. 2013 Nov;122(11):679-82. doi: 10.1177/000348941312201103. After improvement of thyroid function, which generally occurs within 24 hours, iodine can be gradually discontinued and glucocorticoids tapered and discontinued. Patients unable to take PTU or MMI also can be treated with lithium, as use of iodine alone is debatable. Thus, thyroidectomy is a potential therapeutic choice for cases of thyroid storm refractory to medical management. 2017 Aug. 354(2):159-64. Columbia Thyroid Center. thyroid storm with propylthiouracil, hydrocortisone, potassium iodide and propranolol. which can make the diagnosis more difficult. She is the author of "The Thyroid Diet Revolution.". Patients intolerant to iodine can be treated with lithium, which also impairs thyroid hormone release. Your thyroid gland plays a large role in many important bodily functions. She is the author of "The Thyroid Diet Revolution. After thyroidectomy, some people may experience neck pain and a hoarse or weak voice. [7]. If you had a subtotal thyroidectomy and are not immediately put on thyroid hormone medications, watch carefully for symptoms of hypothyroidism and contact your healthcare provider if they occur. [QxMD MEDLINE Link]. Thyroid storm can lead to serious complications if treatment is delayed or if its untreated, including: If youre experiencing symptoms of thyroid storm such as a high fever and a rapid heart rate, get to the nearest emergency room as soon as possible. As with any surgery, it's normal to have questions, concerns, and maybe even feel a little bit of anxiety going into it. [Full Text]. Hyperthyroidism. T3 is triiodothyronine. Its essential to get to the hospital as soon as possible if youre experiencing symptoms of thyroid storm. Thyroid storm may be precipitated by the stress of surgery, anesthesia, or thyroid manipulation and may be prevented by pretreatment with antithyroid drugs (ATDs). The primary reason for concern is that neck bleeding, which can be life-threatening, may occur after a person has returned home after outpatient surgery. South Med J. 2023 Dotdash Media, Inc. All rights reserved, Mary Shomon is a writer and hormonal health and thyroid advocate. Nausea, vomiting, severe diarrhea, abdominal pain, hepatocellular dysfunction-jaundice, 4. eCollection 2022 May. Successful treatment with reserpine in cases of thyroid storm resistant to large doses of propranolol has been documented. 1. 388(10047):906-918. doi:10.1097/MD.0000000000002812, Almquist M, Hallgrimsson P, Nordenstrm E, Bergenfelz A. American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Eating soft foods for the first few days can be helpful. It is uncommon, but when it occurs after thyroidectomy, it is usually associated with Grave's disease. Thyroid Surgery Recovery, Side Effects, and Complications. Prediction of permanent hypoparathyroidism after total thyroidectomy. Diagnosis is primarily clinical, and no specific laboratory tests are available. [QxMD MEDLINE Link]. [1] Improved preoperative management has markedly decreased the incidence of this complication. You may remain in the hospital overnightor be allowed to return home if you had outpatient surgery and are stable. Cooling blankets, ice packs, and alcohol sponges encourage dissipation of heat. T3 is triiodothyronine. Werner and Ingbar'sThe Thyroid: A Fundamental and Clinical Text. What happens after a thyroidectomy depends on how much of the thyroid gland is removed. Akamizu T. Thyroid storm: a Japanese perspective. Less than 1% of people having a thyroidectomy will experience damage to either the recurrent laryngeal nerve or the external branch of the superior laryngeal nerve. Always taking your medication as prescribed by your healthcare provider. Effect on functioning metastases of adenocarcinoma of the thyroid. [Full Text]. [4, 5]. Medicine. Because of this, your healthcare provider may give you antithyroid medication before you have surgery to try to prevent thyroid storm. Thabet Abbarah, MD, FACS is a member of the following medical societies: American College of SurgeonsDisclosure: Nothing to disclose. Your surgeon will talk to you about whether you should continue to wear a dressing over your incision. Acetaminophen and cooling blankets to lower your temperature. Complications after thyroid surgery are rare but can be serious and potentially life threatening. Serious liver injury has been identified with methimazole in 5 cases (3 resulting in death). 2011 Dec. 15(6):522-31. [QxMD MEDLINE Link]. . This case report presents the successful surgical and anaesthesiological management of a patient with Graves' disease, without any signs of perioperative thyroid storm. When you have thyroid storm, the large level of thyroid hormones in your body launches your metabolism into high speed, which is dangerous and life-threatening. Thyroid storm is a complication of hyperthyroidism, so people who have conditions that cause hyperthyroidism, such as Graves disease or a toxic thyroid adenoma, are more likely to get thyroid storm. Mimi S Kokoska, MD Physician, Department of Otolaryngology-Head and Neck Surgery, Aurora Health Care Aulet RM, Wein RO, Siegel RD. Discussion The pathophysiology of thyroid storm is well known. ATD and blockers should be titrated according to thyroid function. Symptoms and Signs of Thyroid Storm When Compared with Uncomplicated Thyrotoxicosis. Presently, esmolol is the ultra-short-acting beta-blocking agent used successfully in thyrotoxicosis and thyroid storm. Approach Considerations The approach to treatment of. when to consider thyroid storm You can ask your surgeon about this prior to your surgery. Other supportive treatments to help with symptoms and side effects. However, there are some things that everyone can expect with any type of thyroid surgery. The boxed warning also states that propylthiouracil should be reserved for use in those who cannot tolerate other treatments such as methimazole, radioactive iodine, or surgery. Endocr Pract. Presently, these techniques are reserved for patients who do not respond to the initial line of management. [7] The criteria established by Burch and Wartofsky help in early recognition of impending storm. Please enable it to take advantage of the complete set of features! 2012 Sep. 109(3):466-7. Ross DS, Burch HB, Cooper DS, et al. . Counsel patients to promptly contact their health care provider for the following signs or symptoms: fatigue, weakness, vague abdominal pain, loss of appetite, itching, easy bruising, or yellowing of the eyes or skin. Radioactive iodine may be used to ablate metastatic deposits and treat thyrotoxicosis. 63(12):1025-64. Transfus Apher Sci. Aulet RM, Wein RO, Siegel RD. 2015 Feb 1. Bleeding into the tissues surrounding the neck, which is known as a neck hematoma, is uncommon, but is potentially life-threatening if not diagnosed and treated promptly. https://www.ncbi.nlm.nih.gov/books/NBK448095/. It produces dramatic improvement in clinical status and greatly ameliorates symptoms. Kulaksizoglu M, Gonen MS, Kebapcilar L, et al. You will probably be able to shower, but should try to keep your neck as dry as possible. Although thyroid storm can develop if you have long-term untreated or undertreated hyperthyroidism, its often caused by a sudden and intense (acute) event or situation. Thyroid storm. Surgical management of an atypical presentation of a thyroid storm.
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